Migraine Prevention

Evidence-based guideline update: Pharmacologic treatment for episodic
migraine prevention in adults.

The author panel reviewed 284 abstracts, which ultimately yielded 29
Class I or Class II articles that are reviewed herein. Divalproex
sodium, sodium valproate, topiramate, metoprolol, propranolol, and
timolol are effective for migraine prevention and should be offered to
patients with migraine to reduce migraine attack frequency and
severity (Level A). Frovatriptan is effective for prevention of
menstrual migraine (Level A). Lamotrigine is ineffective for migraine
prevention (Level A).

Report of the Quality Standards Subcommittee of the American Academy
of Neurology and the American Headache Society Neurology®

The Official Journal of the American Academy of Neurology.